Prof. Dr. Edda Klipp
The Theoretical Biophysics Group comprises a group of theoreticians and experimental researchers developing cutting-edge computational models supported by data. They study the dynamics of various complex biological phenomena by combining computational approaches with experimental methods.
The group is involved in multi-disciplinary research projects to understand cellular organization, cellular processes, stress response, and decision making. Using the yeast Saccharomyces cerevisiae as their major model organism, they develop predictive models of various signaling pathways, metabolic pathways, cell cycle and the interaction of such pathways upon environmental changes. They closely collaborate with various experimental groups for iterative modeling and experimentation.
The mathematical methods include ordinary and partial differential equations, Boolean and Bayesian networks, deterministic and stochastic simulations as well as various aspects of dynamic systems theory. They also develop computational tools for the processing of such models, including parameter estimation, sensitivity analysis and semantic assignments.
Modeling methods
- Ordinary differential equations
- Partial differential equations
- Agent-based modeling
- Boolean models
- Stochastic models
- Constraint-based modeling
- Reaction-contingency based modeling
Data analysis
- Image analysis
- Analysis of periodic behaviour
- Machine learning
Experimental methods
- RNA FISH
- mRNA tracking (MS2)
- Cell wall mechanics and AFM
- Fluorescence microscopy
- FACS
- Molecular biology
- Synchronization
- Cell size analysis
Current position
| 2008 - present | Full Professor of Theoretical Biophysics at the Humboldt-Universität zu Berlin (DE) |
Positions held
| 2022 | Visiting Professor at the Bioinformatics Center, Institute for Chemical Research, Kyoto University (JP) |
| 2007 - 2008 | Guest Professor of Theoretical Biophysics at the Humboldt-Universität zu Berlin (DE) |
| 2006 - 2008 | Group Leader at the Max Planck Institute for Molecular Genetics, Berlin (DE) |
| 2001 - 2006 | Junior Group Leader at the Max Planck Institute for Molecular Genetics, Berlin and Berlin Center for Genome Based Bioinformatics (DE) |
| 1997 - 2001 | Research scientist at the Humboldt-Universität zu Berlin (DE) |
| 1996 - 1997 | Postdoctoral Researcher at the Charité Berlin (DE) |
| 1994 - 1996 | Postdoctoral Researcher at the Humboldt-Universität zu Berlin (DE) |
Academic Education
| 1990 - 1994 | Doctoral Degree in Theoretical Biophysics at the Humboldt-Universität zu Berlin (DE) |
| 1985 - 1990 | Diploma in Biophysics at the Humboldt-Universität zu Berlin (DE) |
Honors/Awards/Fellowships
| 2015 - 2016 | Caroline-von-Humboldt professorship at the Humboldt-Universität zu Berlin (DE) |
| 2009 | Doctor honoris causa from the University of Gothenburg (SE) |
DFG-funded projects
| 2020 - present | DataPLANT - 'Data in PLANT research' |
| 2019 - present | EXC 2046 - 'MATH+: Berlin Mathematics Research Center' |
| 2016 - present | TRR 175 - 'The Green Hub: Central Coordinator of Acclimation in Plants' |
| 2017 - 2022 | GRK 2290 - 'Crossing Boundaries: Molecular Interactions in Malaria' |
| 2011 - 2020 | GRK 1772 - 'Computational Systems Biology' |
| 2011 - 2018 | SFB 740 - 'From Molecules to Modules: Organisation and Dynamics of Functional Units in Cells' |
| 2009 - 2013 | SFB 618 - 'Theoretical Biology: Robustness, Modularity and Evolutionary Design of Living Systems' |
| 2006 - 2010 | GRK 1360 - 'Genomics and Systems Biology of Molecular Networks' |
Selected activities
Selected publications
Coming soon…